The Argument

Ivermectin has been under a lot of scrutiny since the SARS-CoV-2 pandemic began. Some sources will tell you it is nothing more than an anti parasitic drug, or that it is only used as a horse dewormer. Other sources will tell you Ivermectin reduces risk for COVID-19 with very high confidence for mortality, ICU admission, hospitalization, progression, recovery, cases, viral clearance, and in pooled analysis, and high confidence for ventilation.

What is the truth? Let’s walk this one through together, starting with some of the most ‘trusted’ sources…

Government of Canada

The Government of Canada does not support the use of Ivermectin to treat COVID-19.

  • Do not use veterinary ivermectin for the prevention or treatment of COVID-19. If you have purchased ivermectin for this purpose, discard it immediately. Consult a healthcare professional if you have used this product and have health concerns.
  • There is no evidence that ivermectin works to prevent or treat COVID-19, and it is not authorized for this use. To date, Health Canada has not received any drug submission or applications for clinical trials for ivermectin for the prevention or treatment of COVID-19.

SOURCE: https://recalls-rappels.canada.ca/en/alert-recall/ivermectin-not-authorized-prevent-or-treat-covid-19-may-cause-serious-health-problems

Alberta Health Services

AHS does not support the use of Ivermectin to treat COVID-19 patients.

  • There is no evidence that ivermectin benefits COVID-19 patients, but there are known harms. Ivermectin use has been associated with rash, nausea, vomiting, low blood pressure, abdominal pain, tremors, seizures and severe hepatitis (liver disease) requiring hospitalization.
  • Further, the use of veterinary versions of ivermectin is risky because they may contain ingredients not used in medications for humans, and are meant for use in much larger animals like horses and cattle. Ingestion of large amounts of veterinary ivermectin can cause poisoning and even lead to death.

SOURCE: https://www.albertahealthservices.ca/news/releases/2021/Page16218.aspx

U.S. Food & Drug Administration

The FDA is not in support of using Ivermectin to treat COVID-19.

  • Currently available data do not show ivermectin is effective against COVID-19. Clinical trials assessing ivermectin tablets for the prevention or treatment of COVID-19 in people are ongoing.
  • Never use medications intended for animals on yourself or other people. Animal ivermectin products are very different from those approved for humans. Use of animal ivermectin for the prevention or treatment of COVID-19 in humans is dangerous.

SOURCE: https://www.fda.gov/consumers/consumer-updates/why-you-should-not-use-ivermectin-treat-or-prevent-covid-19

National Institute of Health

The NIH does not support the use of Ivermectin to treat COVID-19.

  • There is insufficient evidence for the COVID-19 Treatment Guidelines Panel (the Panel) to recommend either for or against the use of ivermectin for the treatment of COVID-19. Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide more specific, evidence-based guidance on the role of ivermectin in the treatment of COVID-19

SOURCE: https://www.covid19treatmentguidelines.nih.gov/therapies/antiviral-therapy/ivermectin/

World Health Organization

WHO does not support the use of Ivermectin to treat COVID-19 patients.

  • The group reviewed pooled data from 16 randomized controlled trials (total enrolled 2407), including both inpatients and outpatients with COVID-19. They determined that the evidence on whether ivermectin reduces mortality, need for mechanical ventilation, need for hospital admission and time to clinical improvement in COVID-19 patients is of “very low certainty,” due to the small sizes and methodological limitations of available trial data, including small number of events.
  • The panel did not look at the use of ivermectin to prevent COVID-19, which is outside of scope of the current guidelines.

SOURCE: https://www.who.int/news-room/feature-stories/detail/who-advises-that-ivermectin-only-be-used-to-treat-covid-19-within-clinical-trials

Summary from the ‘trusted sources’

All of these sources seem to say that the currently available data DOES NOT show that the use of Ivermectin is beneficial to COVID-19 patients.

Now, we could obviously just say that they ‘must be correct’, because these sources have public health at the top of their priority list. However, those of us at Warhorses very much believe that being critical and digging deeper is the only way to fully understand the consensus. These statements from ‘trusted’ sources lead us to the following questions:

  1. What is the currently available data? Where can I find it and what does it say?
  2. Why do these sources say ‘no evidence’? Is there actually zero studies on the effectiveness of this treatment for COVID 19?
  3. What exactly is the point of saying that animal Ivermectin is not safe for humans? We are searching for data on the human version, aren’t we?
  4. Why did the WHO not look at the use of ivermectin to prevent COVID-19? Do we have studies that have been peer reviewed since this statement was released?

To find out, we will have to take a look at Ivermectin from another viewpoint…

Unicorn

Currently Available Data

What is the currently available data? Where can I find it and what does it say?

Lack of Evidence?

Why do the ‘trusted’ sources say ‘no evidence’? Is there actually zero studies on the effectiveness of this treatment for COVID 19?

Evidence for Ivermectin

There is obviously some evidence to support the use of Ivermectin to treat COVID-19. To start with, we suggest looking at the following website for a meta-analysis of the situation: https://ivmmeta.com/

Surprisingly, the evidence supporting Ivermectin for COVID-19 far exceeds the typical amount of evidence used for the approval of treatments. See the table below, which compares other COVID-19 approvals with the Ivermectin evidence base:


Medication Studies Patients Improvement Status
Molnupiravir (UK) 1 775 50% Approved
Budesonide (UK) 1 1,779 17% Approved
Remdesivir (USA EUA) 1 1,063 31% Approved
Casiri/imdevimab (USA EUA) 1 799 66% Approved
Ivermectin evidence 78 85,743 64% [57‑70%] Pending

Is it only a Horse Dewormer?

What exactly is the point of saying that animal Ivermectin is not safe for humans? We are searching for data on the human version, aren’t we?

Obviously humans should not be taking medication for animals; is mentioning the use of the equine version of the drug intended as a safety precaution? Or is it just simply a propaganda tool our ‘trusted sources’ are promoting?

Could the persecution of doctors and pharmacists who prescribed ivermectin in Canada be considered a confounding factor? If human ivermectin was no longer available to the public, would that increase or decrease the amount of people seeking veterinary drugs?

At the end of this article there is a questionnaire to see how many people chose to use the equine version of Ivermectin, only because the human version was made almost impossible to obtain in Canada. This is a major factor which does not seem to be under much scrutiny.

FDA Analysis: https://ivmmeta.com/#fda

The FDA notes that they “received multiple reports of patients who have required medical support and been hospitalized after self-medicating with ivermectin intended for horses”. The number of reports was 4 [Pfeiffer]. For comparison, acetaminophen overdose results in ~33,000 yearly hospitalizations in the USA (~12,000 unintentional) [Charilaou]. The FDA’s recommendation may increase cases of self-medication with animal ivermectin, because it reduces the percentage of prescribing physicians.

Dosage differences

So, the narrative also seems to suggest that the dosage for animals is too much for a human being. Let’s take a look at the table below, which shows some of the differences between dosages:

Condition Dosage
Human River Blindness 150 mcg/kg
Human Strongyloidiasis 200 mcg/kg
Use in Horses 200 mcg/kg
Human COVID-19 200 mcg/kg

So now we have determined that the dosages being suggested for humans are pretty much the same as horses. It is fairly obvious that you should not take the amount of Ivermectin intended for a 1000+ pound animal. I am positive that a prescribing physician would know how to calculate a dosage for their individual patient.

All this being said, there are differences between the equine and human versions of the drug. Certain additives (not for humans) are used in the equine version of the drug and (obviously) the human version is intended for use in humans.

Prevention of COVID-19

Why did the WHO not look at the use of ivermectin to prevent COVID-19? Do we have studies that have been peer reviewed since this statement was released?

As of today (Feb. 10, 2022), there are 16 studies which include 19, 365 patients. These studies conclude there is an 83% [50‑100%] improvement when Ivermectin is used as a prophylactic treatment.

SOURCE: https://ivmmeta.com/#fig_fp

There is no good way to judge why the World Health Organization did not look at this data. Let us assume the best and say they were simply just being lazy, and borderline negligent with the public health they serve to protect.

Conclusion

Ivermectin is an effective treatment for COVID-19. The ‘trusted sources’ have been fact checked and it is the determination of Warhorses that they are either intentionally or accidentally distributing false information.

The currently available data suggests that ivermectin has 19 times more evidence to showing efficacy against COVID-19, compared to Molnupiravir, Budesonide, Remdesivir and Monoclonal Antibodies combined.

Warhorses finds it very disconcerting that our most ‘trusted sources’ are so blatantly failing to represent the science. This should be addressed to determine whether the information being provided about ivermectin should be considered misinformation or disinformation.

The statements of these ‘trusted sources’ could easily be considered denial of available data. Denying the efficacy of treatments increases mortality, morbidity, collateral damage, and endemic risk. These organizations should be held accountable for any and all excess deaths related to the use of equine ivermectin and/or denying life saving treatments to patients.

Please see our detailed analysis of their statements below:

Government of Canada
  • Do not use veterinary ivermectin for the prevention or treatment of COVID-19. If you have purchased ivermectin for this purpose, discard it immediately. Consult a healthcare professional if you have used this product and have health concerns. VIEW SOURCE
    • This information is MISLEADING. There is no reason to use the equine version of Ivermectin because there is a widely available human version of the drug. How many people have taken the veterinary ivermectin because this ‘trusted source’ chooses to persecute doctors who try to provide the treatment with a proper prescription?
  • There is no evidence that ivermectin works to prevent or treat COVID-19, and it is not authorized for this use. To date, Health Canada has not received any drug submission or applications for clinical trials for ivermectin for the prevention or treatment of COVID-19. VIEW SOURCE
    • This information is FALSE and MISLEADING. There are over 48 peer reviewed studies on the effectiveness of Ivermectin in treatment of COVID-19.
Alberta Health Services
  • There is no evidence that ivermectin benefits COVID-19 patients, but there are known harms. Ivermectin use has been associated with rash, nausea, vomiting, low blood pressure, abdominal pain, tremors, seizures and severe hepatitis (liver disease) requiring hospitalization. VIEW SOURCE
    • This information is FALSE and MISLEADING. There are over 48 peer reviewed studies on the effectiveness of Ivermectin in treatment of COVID-19.
  • Further, the use of veterinary versions of ivermectin is risky because they may contain ingredients not used in medications for humans, and are meant for use in much larger animals like horses and cattle. Ingestion of large amounts of veterinary ivermectin can cause poisoning and even lead to death. VIEW SOURCE
    • This information is MISLEADING. There is no reason to use the equine version of Ivermectin because there is a widely available human version of the drug. How many people have taken the veterinary ivermectin because this ‘trusted source’ chooses to persecute doctors who try to provide the treatment with a proper prescription?
U.S. Food & Drug Administration

The FDA is not in support of using Ivermectin to treat COVID-19.

  • Currently available data do not show ivermectin is effective against COVID-19. Clinical trials assessing ivermectin tablets for the prevention or treatment of COVID-19 in people are ongoing. VIEW SOURCE
    • This information is FALSE and MISLEADING. There are over 48 peer reviewed studies on the effectiveness of Ivermectin in treatment of COVID-19.
  • Never use medications intended for animals on yourself or other people. Animal ivermectin products are very different from those approved for humans. Use of animal ivermectin for the prevention or treatment of COVID-19 in humans is dangerous. VIEW SOURCE
    • This information is MISLEADING. There is no reason to use the equine version of Ivermectin because there is a widely available human version of the drug. How many people have taken the veterinary ivermectin because this ‘trusted source’ chooses to persecute doctors who try to provide the treatment with a proper prescription?
National Institute of Health
  • There is insufficient evidence for the COVID-19 Treatment Guidelines Panel (the Panel) to recommend either for or against the use of ivermectin for the treatment of COVID-19. Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide more specific, evidence-based guidance on the role of ivermectin in the treatment of COVID-19. VIEW SOURCE
    • This information is FALSE and MISLEADING. There are over 48 peer reviewed studies on the effectiveness of Ivermectin in treatment of COVID-19.
World Health Organization
  • The group reviewed pooled data from 16 randomized controlled trials (total enrolled 2407), including both inpatients and outpatients with COVID-19. They determined that the evidence on whether ivermectin reduces mortality, need for mechanical ventilation, need for hospital admission and time to clinical improvement in COVID-19 patients is of “very low certainty,” due to the small sizes and methodological limitations of available trial data, including small number of events. VIEW SOURCE
    • This information is FALSE and MISLEADING. There are over 48 peer reviewed studies on the effectiveness of Ivermectin in treatment of COVID-19.
  • The panel did not look at the use of ivermectin to prevent COVID-19, which is outside of scope of the current guidelines. VIEW SOURCE
    • This information is WEAK and MISLEADING. As of today (Feb. 8, 2022), there are 16 studies which include 19, 365 patients. These studies conclude there is an 83% [50‑100%] improvement when Ivermectin is used as a prophylactic treatment. The scope of the current guidelines should absolutely include prophylaxis in an effort to avoid medical negligence.

Disclaimer

This information is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this analysis is for informational and educational purposes only.

Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information on this website should ever be considered as a substitute for advice from a healthcare professional.

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